Structural and Functional Characterization of the Immunoproteasome [electronic resource] /by Eva Maria Huber.
by Huber, Eva Maria [author.]; SpringerLink (Online service).
Material type:
BookSeries: Springer Theses, Recognizing Outstanding Ph.D. Research: Publisher: Cham : Springer International Publishing : 2013.Description: XIX, 82 p. 33 illus., 29 illus. in color. online resource.ISBN: 9783319015569.Subject(s): Chemistry | Analytical biochemistry | Biochemistry | Chemistry | Analytical Chemistry | Protein Science | Medicinal ChemistryDDC classification: 543 Online resources: Click here to access online | Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| MAIN LIBRARY | QD71-142 (Browse shelf) | Available |
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| QH540-549.5 Tewkesbury Walks | TK7867-7867.5 Advanced Materials for Integrated Optical Waveguides | HB848-3697 Handbook of Palaeodemography | QD71-142 Structural and Functional Characterization of the Immunoproteasome | K3581-3598.22 On Political Culture, Cultural Policy, Art and Politics | HQ1-2044 Emerging Methods in Family Research | QA299.6-433 Topics in Fixed Point Theory |
Introduction -- Objective -- Materials and Methods -- Results -- Discussion -- Appendix.
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.
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