Evolution Toward Next Generation Internet (ENGI) -- General Purpose Computation on Graphics Hardware (GPGPU): Methods, Algorithms and Applications -- Intelligent and Collaborative System Integration Technology (ICSIT) -- Computational Methods for Financial Markets -- International Workshop on P2P for High Performance Computational Sciences (P2P-HPCS06) -- Computational Finance and Business Intelligence -- Third International Workshop on Automatic Differentiation Tools and Applications -- Workshop on Scientific Computing in Electronics Engineering -- New Trends in the Numerical Solution of Structured Systems with Applications -- Workshop on Computational Science in Software Engineering (CSSE’06) -- Digital Human Modeling (DHM-06) -- Real Time Systems and Adaptive Applications (RTSAA 06) -- International Workshop on Grid Computing Security and Resource Management (GSRM’06) -- Fourth International Workshop on Autonomic Distributed Data and Storage Systems Management Workshop (ADSM 2006).

The four-volume set LNCS 3991-3994 constitutes the refereed proceedings of the 6th International Conference on Computational Science, ICCS 2006, held in Reading, UK, in May 2006. The main conference and its 32 topical workshops attracted over 1400 submissions. The 98 revised full papers and 29 revised poster papers of the main track presented together with 500 accepted workshop papers were carefully reviewed and selected for inclusion in the four volumes. The papers span the whole range of computational science, with focus on the following major themes: tackling grand challenges problems; modelling and simulations of complex systems; scalable algorithms and tools and environments for computational science. Of particular interest were the following major recent developments in novel methods and modelling of complex systems for diverse areas of science, scalable scientific algorithms, advanced software tools, computational grids, advanced numerical methods, and novel application areas where the above novel models, algorithms and tools can be efficiently applied such as physical systems, computational and systems biology, environmental systems, finance, and others.