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Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia [electronic resource] /by Anton B. Tonchev, George N. Chaldakov, Tetsumori Yamashima.

by Tonchev, Anton B [author.]; Chaldakov, George N [author.]; Yamashima, Tetsumori [author.]; SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Advances in Anatomy Embryology and Cell Biology: 191Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2007.Description: X, 108 p. 65 illus. online resource.ISBN: 9783540396178.Subject(s): Medicine | Neurosciences | Biomedicine | NeurosciencesDDC classification: 612.8 Online resources: Click here to access online
Contents:
1 Introduction.-.1 Studies on cell proliferation in adult primate brain -- 1.2 Methodological considerations in detecting cell proliferation -- 1.3 Cell proliferation in rodent brain after ischemia -- 1.4 Global cerebral ischemia in primates -- 2 Materials and Methods -- 2.1 Animal subjects -- 2.2 Bromodeoxyuridine infusion protocol -- 2.3 Tissue processing -- 2.4 Immunohistochemistry -- 2.5 Detection of DNA damage and degenerating cells -- 2.6 Electron microscopy -- 2.7 Image acquisition and analysis -- 2.8 Statistical analysis -- 3 Results -- 3.1 Hippocampal formation -- 3.1.1 Dentate gyrus -- 3.1.2 Cornu Ammonis -- 3.1.3 Subiculum -- 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi) -- 3.3 Temporal lobe -- 3.3.1 Parahippocampal region -- 3.3.2 Temporal neocortex -- 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa) -- 3.5 Rostral migratory stream and olfactory bulb -- 3.6 Frontal neocortex and striatum -- 4 Discussion -- 4.1 BrdU as a proliferation marker -- 4.2 Effects of ischemia on cell proliferation and differentiation -- 4.3 Sustained progenitor cell existence in germinative zones -- 4.4 Implications of monkey findings for therapies in humans -- 5 Summary -- References -- Subject Index.
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1 Introduction.-.1 Studies on cell proliferation in adult primate brain -- 1.2 Methodological considerations in detecting cell proliferation -- 1.3 Cell proliferation in rodent brain after ischemia -- 1.4 Global cerebral ischemia in primates -- 2 Materials and Methods -- 2.1 Animal subjects -- 2.2 Bromodeoxyuridine infusion protocol -- 2.3 Tissue processing -- 2.4 Immunohistochemistry -- 2.5 Detection of DNA damage and degenerating cells -- 2.6 Electron microscopy -- 2.7 Image acquisition and analysis -- 2.8 Statistical analysis -- 3 Results -- 3.1 Hippocampal formation -- 3.1.1 Dentate gyrus -- 3.1.2 Cornu Ammonis -- 3.1.3 Subiculum -- 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi) -- 3.3 Temporal lobe -- 3.3.1 Parahippocampal region -- 3.3.2 Temporal neocortex -- 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa) -- 3.5 Rostral migratory stream and olfactory bulb -- 3.6 Frontal neocortex and striatum -- 4 Discussion -- 4.1 BrdU as a proliferation marker -- 4.2 Effects of ischemia on cell proliferation and differentiation -- 4.3 Sustained progenitor cell existence in germinative zones -- 4.4 Implications of monkey findings for therapies in humans -- 5 Summary -- References -- Subject Index.

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