Orphan G Protein-Coupled Receptors and Novel Neuropeptides [electronic resource] /edited by Olivier Civelli, Qun-Yong Zhou.
by Civelli, Olivier [editor.]; Zhou, Qun-Yong [editor.]; SpringerLink (Online service).
Material type:
BookSeries: Results and Problems in Cell Differentiation: 46Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2008.Description: online resource.ISBN: 9783540783510.Subject(s): Life sciences | Neurosciences | Toxicology | Endocrinology | Cytology | Neurobiology | Life Sciences | Neurobiology | Pharmacology/Toxicology | Endocrinology | Neurosciences | Cell BiologyDDC classification: 573.8 Online resources: Click here to access online | Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| MAIN LIBRARY | QP351-495 (Browse shelf) | Available |
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| QA297-299.4 Mixed Finite Elements, Compatibility Conditions, and Applications | TK1-9971 Usability of Speech Dialog Systems | Photonic Crystals | QP351-495 Orphan G Protein-Coupled Receptors and Novel Neuropeptides | QH324.2-324.25 Bioinformatics and Systems Biology | RC870-923.2 Andrology | QA370-380 Multiscale Problems in the Life Sciences |
The Orphanin FQ/Nociceptin (OFQ/N) System -- Orexins and Orexin Receptors: From Molecules to Integrative Physiology -- Prolactin-Releasing Peptide -- Structure and Function of Ghrelin -- GPR54 and Kisspeptins -- Neuropeptide S: Anatomy, Pharmacology, Genetics and Physiological Functions -- The Melanin-Concentrating Hormone System and Its Physiological Functions -- Biological Function of Prokineticins -- Neuromedin S: Discovery and Functions -- Relaxin-3, INSL5, and Their Receptors -- The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion.
Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.
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