From Precursor to Cancer: Field Cancerization and the Opportunities for Therapy -- When Is a Skin Cancer a Cancer: The Histopathologist’s View -- Epidemiology of Non-Melanoma Skin Cancer -- Genetics of Non-Melanoma Skin Cancers and Associated Familial Syndromes -- Environmental Risk Factors for Non-Melanoma Skin Cancers -- Accuracy in the Diagnosis of Non-Melanoma Skin Cancer -- Cure Rates Following Surgical Therapy — The Golden Standard -- Pharmacological Therapy: An Introduction -- Systemic Chemotherapy of Non-Melanoma Skin Cancer -- Intralesional Agents to Manage Cutaneous Malignancy -- Topical Chemotherapy -- Immunotherapy: An Introduction -- Intralesional Interferon in the Treatment of Basal Cell Carcinoma -- Interleukin-2 for Nonmelanoma Skin Cancer -- Topical Imiquimod -- Photodynamic Therapy -- Critical Evidence-Based Review of Current Experience and Possible Future Developments of Topical PDT -- Electrochemotherapy in Treatment of Cutaneous Tumors -- Radiotherapy: At a Glance -- Prevention and Adjuvant Therapy -- Sunscreens -- Skin Cancer: Antioxidants and Diet -- Retinoids in the Management of Non-Melanoma Skin Cancer -- PDT for Cancer Prevention -- Dermabrasion, Laser Resurfacing, and Photorejuvenation for Prevention of Non-Melanoma Skin Cancer -- To Cut or Not, That Is the Question.

With more and more patients suffering from field cancerisation, an alternative for repeated surgery for the diagnosis and treatment of non-melanoma skin cancer is becoming necessary. Although surgery remains the gold standard for treatment of non-melanoma or keratinocyte skin cancer, it also has its downside. Surgery leaves scars and nowadays the cosmetic outcome of therapy is becoming increasingly important. Since many cases can effectively be managed without surgery, the possibilities of non-surgical therapy are gaining popularity, particularly in low malignancy tumours. This reader-friendly clinical guide offers treatment options for the growing group of these patients. It describes the current state-of-the art for non-surgical treatment of this type of skin cancer, and gives factual knowledge to beginners and new inspirations to experts.