Koha online

Your cart is empty.
Normal view MARC view ISBD view

Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B [electronic resource] /by Xiao-Yu Sun.

by Sun, Xiao-Yu [author.]; SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Springer Theses: Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2012.Description: XIV, 220p. 308 illus., 12 illus. in color. online resource.ISBN: 9783642271953.Subject(s): Chemistry | Chemistry, Organic | Biochemistry | Catalysis | Chemistry | Organic Chemistry | Medicinal Chemistry | CatalysisDDC classification: 547 Online resources: Click here to access online
Contents:
Introduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II.
In: Springer eBooksSummary: In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Tags from this library: No tags from this library for this title. Add tag(s)
Log in to add tags.
    average rating: 0.0 (0 votes)
Item type Current location Call number Status Date due Barcode
MAIN LIBRARY
QD415-436 (Browse shelf) Available

Introduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II.

In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.

There are no comments for this item.

Log in to your account to post a comment.
@ Jomo Kenyatta University Of Agriculture and Technology Library

Powered by Koha