Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones [electronic resource] :An Approach through Asymmetric Organocatalysis / by Corinna Reisinger.
by Reisinger, Corinna [author.]; SpringerLink (Online service).
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BookSeries: Springer Theses, Recognizing Outstanding Ph.D. Research: Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : 2012.Description: XV, 257 p. 469 illus., 42 illus. in color. online resource.ISBN: 9783642281181.Subject(s): Chemistry | Chemistry, Organic | Chemical engineering | Catalysis | Chemistry | Organic Chemistry | Catalysis | Industrial Chemistry/Chemical EngineeringDDC classification: 547 Online resources: Click here to access online | Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| MAIN LIBRARY | QD415-436 (Browse shelf) | Available |
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| RB155-155.8 JIMD Reports - Case and Research Reports, 2012/2 | QA75.5-76.95 The Universal Machine | KZ7000-7500 The Matrix of Derivative Criminal Liability | QD415-436 Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones | QD415-436 Radicals in Synthesis III | RC86-88.9 Management of Severe Traumatic Brain Injury | RB155-155.8 JIMD Reports - Case and Research Reports, 2012/3 |
Background -- Asymmetric Organocatalysis -- Catalytic Asymmetric Epoxidation of Electron-Deficient Olefins -- Synthesis and Relevance of 3-Hydroxy-1,2-dioxolanes and 1,2-Dioxolanes -- Objectives of this Ph.D. Work -- Results and Discussion -- Catalytic Asymmetric Epoxidation of Cyclic Enones -- Catalytic Asymmetric Epoxidation and Hydroperoxidation of Acyclic Enones -- Synthetic Transformations of Optically Active a,ß-Epoxy Ketones and 3-Hydroxy-1,2-dioxolanes -- Summary and Conclusions -- Mechanistic Considerations -- Preparation of Starting Materials -- Catalyst Synthesis -- Summary -- Outlook -- Experimental Part -- General Experimental Conditions -- Catalytic Asymmetric Epoxidation of Cyclic Enones -- Catalytic Asymmetric Hydroperoxidation and Epoxidation of Acyclic Enones -- Synthetic Transformations of Optically Active Products -- Preparation of Starting Materials -- Catalyst Synthesis.
Corinna Reisinger has developed a new organocatalytic asymmetric epoxidation of cyclic and acyclic α,β-unsaturated ketones. In this thesis, Corinna documents her methodology, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant. She describes the unprecedented and powerful catalytic asymmetric hydroperoxidation of α,β-enones, a process which produces optically active five-membered cyclic peroxyhemiketals in a single operation. She also proves the versatility and synthetic value of the cyclic peroxyhemiketals by converting them into highly enantioenriched acyclic and cyclic aldol products. Currently, these cyclic aldol products are inaccessible by any other synthetic means. Furthermore, cyclic peroxyhemiketals are precursors to optically active 1,2-dioxolanes which are of biological relevance. This work is a breakthrough in the field of asymmetric epoxidation chemistry and outlines the most efficient method in the literature for generating highly enantioselective cyclic epoxyketones known to date.
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