Handbook of animal models in Alzheimer's disease / edited by Gemma Casadesus.
by Casadesus, Gemma.
Material type:
BookSeries: Advances in Alzheimer's disease: v. 1.Publisher: Amsterdam ; Washington DC : IOS Press, c2011Description: x, 340 p. : ill.ISBN: 1607507323; 9781607507321.Subject(s): Alzheimer's disease -- Animal models | Diseases -- Animal modelsDDC classification: 616.831 Summary: Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals - including transgenic animals - has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| Long Loan | MOMBASA CBD CAMPUS | RC523 .H35 2011 (Browse shelf) | Available | 126593 |
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| RC489.M43 W55 2011 Mindfulness : | RC509 .M459 The Freedom to Inquire: | RC516 .S78 1998 His bright light : | RC523 .H35 2011 Handbook of animal models in Alzheimer's disease / | RC523.2 A443 2006 Alzheimer's disease / | RC523.2 .A45 2008 Alzheimer disease sourcebook : | RC531 .F87 2007 Treating Health Anxiety and Fear of Death |
Includes bibliographical references and index.
Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals - including transgenic animals - has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.
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