MIRRs: Structure and Physiological Function -- T-Cell Receptor -- B-Cell Receptor -- Fc Receptors -- Natural Killer Cell Receptors -- Platelet Glycoprotein VI -- MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize -- Clustering Models -- Segregation Models -- Kinetic Proofreading Model -- Serial Triggering Model -- Conformational Model -- Permissive Geometry Model -- Signaling Chain Homooligomerization (SCHOOL) Model -- Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses -- Visualization of Protein Interactions in Living Cells -- MIRR Signaling and Therapy of Immune Disorders -- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences -- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides -- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer -- Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease -- MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines -- SCHOOL Model and New Targeting Strategies -- Immune Receptor Signaling, Aging and Autoimmunity -- Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment.

This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transduction will be shortly reviewed in Section 3. This book will summarize our current knowledge in this field and illustrate how control of the MIRR-triggered signaling could become a potential target of medical intervention, thus bridging basic and clinical immunology.