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Toll and Toll-Like Receptors: An Immunologic Perspective [electronic resource] /by Tina Rich.

by Rich, Tina [author.]; SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Molecular Biology Intelligence Unit: Publisher: Boston, MA : Springer US, 2005.Description: X, 218 p. online resource.ISBN: 9780387274454.Subject(s): Life sciences | Immunology | Cytology | Life Sciences | Cell Biology | ImmunologyDDC classification: 571.6 Online resources: Click here to access online
Contents:
The Function of Toll-Like Receptors -- Structures and Motifs Involved in Toll Signaling -- “Supramolecular” Activation Clusters in Innate Immunity -- Interleukin-1 Receptor/Toll-Like Receptor Signaling -- Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response -- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling -- Pathogen Avoidance Using Toll Signaling in C. elegans -- Forward Genetic Analysis of TLR Pathways -- Agonists of Toll-Like Receptor 9.
In: Springer eBooksSummary: Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these ‘higher’ immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self – non-self recognition.
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The Function of Toll-Like Receptors -- Structures and Motifs Involved in Toll Signaling -- “Supramolecular” Activation Clusters in Innate Immunity -- Interleukin-1 Receptor/Toll-Like Receptor Signaling -- Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response -- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling -- Pathogen Avoidance Using Toll Signaling in C. elegans -- Forward Genetic Analysis of TLR Pathways -- Agonists of Toll-Like Receptor 9.

Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these ‘higher’ immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self – non-self recognition.

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