Fas Signaling [electronic resource] /by Harald Wajant.
by Wajant, Harald [author.]; SpringerLink (Online service).
Material type:
BookSeries: Medical Intelligence Unit: Publisher: Boston, MA : Springer US, 2006.Description: VIII, 160 p. online resource.ISBN: 9780387345734.Subject(s): Medicine | Immunology | Oncology | Biomedicine | Immunology | Molecular Medicine | OncologyDDC classification: 616.079 Online resources: Click here to access online
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Springer eBooksSummary: Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.
FasL and Fas -- FasL-Independent Activation of Fas -- Role of Ceramide in CD95 Signaling -- Regulation of Fas Signaling by FLIP Proteins -- Fas-Induced Necrosis -- Fas—More Than an Apoptosis Inducer -- Retrograde Fas Ligand Signaling -- FasL and Fas in Liver Homeostasis and Hepatic Injuries -- Fas-Activation, Development and Homeostasis of T Cells -- The FasL-Fas System in Disease and Therapy -- Tools for Activation and Neutralization of Fas Signaling.
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