General Mechanisms of Transformation -- Theories of Carcinogenesis -- Physiologic Correlates of Malignancy -- Alterations Intrinsic to the Tumor Cells -- Cell Division and Survival -- Cellular Senescence -- Invasiveness -- Mechanisms of Regulation of Cancer-related Genes -- DNA Repair -- Epigenetic Regulation of Cancer-Associated Gene Products -- Interaction of the Groups of Cancer-Related Gene Products -- Interactions Between Host and Tumor -- Structural Growth Control -- The Organ Preference of Metastasis Formation -- Angiogenesis -- Interactions with the Immune System -- Endocrine Dysregulation -- Dormancy and Minimal Residual Disease -- Molecular Mechanisms of Individual Malignancies -- Epithelial Tumors -- Hematologic Malignancies -- Mesenchymal Tumors -- Neurologic Tumors -- Tumors of Serous Cavities -- Embryonic Tumors.

The knowledge of molecular defects that lead to cancer is increasing rapidly. This has created a need for a textbook that conveys a comprehensive review of this topic. "Molecular Mechanisms of Cancer", describes molecular processes whose deregulation is important in the formation of tumours. The material is developed from basic cell signalling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumour cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumour-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers. This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets. The growing insight generated by research into molecular carcinogenesis and the absence of comparably comprehensive and systematic textbooks makes this publication important and timely.