Protein Tyrosine Phosphatase Control of Metabolism [electronic resource] /edited by Kendra K. Bence.
by Bence, Kendra K [editor.]; SpringerLink (Online service).
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MAIN LIBRARY | QD431-431.7 (Browse shelf) | Available |
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RC321-580 Deafness | QA276-280 Topics in Applied Statistics | RC927-927.5 Skin Manifestations in Rheumatic Disease | QD431-431.7 Protein Tyrosine Phosphatase Control of Metabolism | TK1-9971 Analysis of TCP Performance in Data Center Networks | QA641-670 Introduction to Tensor Analysis and the Calculus of Moving Surfaces | KZA1002-5205 Fundamentals of Space Law and Policy |
Redox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index.
Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism.
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