The meeting of minds and times with Peter Riederer: an appreciation -- Succi nervorum: a brief history of neurochemistry -- Neuronal differentiation and long-term culture of the human neuroblastoma line SH-SY5Y -- Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain -- Lipid content determines aggregation of neuromelanin granules in vitro -- Hydrogen peroxide is a true first messenger -- The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders -- Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis -- Luteolin protects rat PC 12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keapl-Nrf2-ARE pathway -- Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals -- Animal models in neurodegenerative diseases -- Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study -- Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture -- Biochemistry of postmortem brains in Parkinson’s disease: historical overview and future prospects -- Neuroprotection by propargylamines in Parkinson’s disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers -- Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson’s disease -- Low dose methylphenidate improves freezing in advanced Parkinson’s disease during off-state -- The long-term effects of the neurotoxin l-trichloromethyl-1,2,3,4-tetrahydro-?-carboline (TaClo) on cognitive performance in rats -- Observations on the cortical silent period in Parkinson’s disease -- CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity -- Pharmacokinetic studies of (—)-deprenyl and some of its metabolites in mouse -- Serum lipoprotein profile and APOE genotype in Alzheimer’s disease -- VITA study: white matter hyperintensities of vascular and degenerative origin in the elderly -- ?-Lipoic acid as a new treatment option for Alzheimer’s disease — a 48 months follow-up analysis -- Long-term abnormalities in brain glucose/energy metabolism after inhibition of the neuronal insulin receptor: implication of tau-protein -- Long-term tetrahydroaminoacridine treatment and quantitative EEG in Alzheimer’s disease -- Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease -- Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach -- Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’s disease and diabetes mellitus -- Improving linear modeling of cognitive decline in patients with mild cognitive impairment: comparison of two methods -- Interaction of attention and graphomotor functions in children with attention deficit hyperactivity disorder -- Therapeutic drug monitoring of antidepressants — clinical aspects -- The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view -- Deficits of neuronal glutamatergic markers in the caudate nucleus in schizophrenia -- Therapeutic drug monitoring of tricyclic antidepressants in everyday clinical practice -- FZD3 is not a risk gene for schizophrenia: a case-control study in a Caucasian sample -- Impaired cortical inhibition in adult ADHD patients: a study with transcranial magnetic stimulation* -- Association of Parkinson’s disease with symptoms of attention deficit hyperactivity disorder in childhood -- Biostatistical analysis of gene microarrays reveals diverse expression clusters between macaque subspecies in brain SIV infection -- Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis -- Neural stem cell transplantation in a model of fetal alcohol effects.

This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders, such as Parkinson´s and Alzheimer´s disease and new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders, such as attention deficit-hyperactivity disorders and schizophrenia, and therapeutic drug-monitoring of antidepressants.The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement in April 2007. It will be a valuable resource for neurologists, psychiatrists and neuroscientists.